Second-trimester soft markers: relation to first-trimester nuchal translucency in unaffected pregnancies

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Second-trimester soft markers: relation to first-trimester nuchal translucency in unaffected pregnancies.

OBJECTIVE Genetic sonography following first-trimester combined screening appears to increase substantially detection rates for Down syndrome but it relies on the unproved assumption of independence between these tests. In this study we aimed to investigate the relationship between first-trimester nuchal translucency (NT) and a series of second-trimester soft markers and structural defects in u...

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First trimester risk assessment for trisomy 21 in twin pregnancies combining nuchal translucency and first trimester biochemical markers.

OBJECTIVE The aim is to describe the performance of first-trimester combined risk assessment in twin pregnancies. METHODS Maternal serum free beta-human chorionic gonadotrophin and pregnancy-associated plasma protein A (PAPP-A) were determined at 8 to 12 weeks and fetal nuchal translucency (NT) was measured at 11 to 13+6 weeks. The individual risk was estimated for each fetus using the combin...

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Evaluation of Nuchal Translucency Measuremen in First Trimester Pregnancy

Background A significant number of pregnancies, particularly in women with previous histories of infertility, are associated with fetal abnormalities. Methods such as the nuchal translucency (NT) measurement enable us to identify more pregnancies with chromosomal abnormalities. MaterialsAndMethods This analytic cross-sectional study was performed in 446 pregnant women at 11-14 weeks gestation, ...

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Nuchal translucency measurement in first trimester Down syndrome screening.

(1) Approximately three in every four fetuses with Down syndrome have increased nuchal translucency (NT), which is a larger than normal build-up of fluid at the back of the neck. (2) The ultrasound measurement of NT between 11 and 14 weeks' gestation, in combination with the mother's age and the levels of placental biochemical markers in her blood, can be used to detect approximately 84% of fet...

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Evaluation of Nuchal Translucency Measurement in First Trimester Pregnancy

BACKGROUND A significant number of pregnancies, particularly in women with previous histories of infertility, are associated with fetal abnormalities. Methods such as the nuchal translucency (NT) measurement enable us to identify more pregnancies with chromosomal abnormalities. MATERIALS AND METHODS This analytic cross-sectional study was performed in 446 pregnant women at 11-14 weeks gestati...

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ژورنال

عنوان ژورنال: Ultrasound in Obstetrics & Gynecology

سال: 2012

ISSN: 0960-7692

DOI: 10.1002/uog.9024